No Evidence for Association of -2518 A/G Promoter Polymorphism of MCP-1 with Risk of Esophageal Cancer in Punjab, North-West India
Vasudha Sambyal
Human Cytogenetics Laboratory, Department of Human Genetics, Guru Nanak Dev University, Amritsar 143005, Punjab, India
Kamlesh Guleria *
Human Cytogenetics Laboratory, Department of Human Genetics, Guru Nanak Dev University, Amritsar 143005, Punjab, India
Mridu Manjari
Department of Pathology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
Meena Sudan
Department of Radiotherapy, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
Manjit Singh Uppal
Department of Surgery, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
Neeti Rajan Singh
Department of Surgery, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India
*Author to whom correspondence should be addressed.
Abstract
Aim: To investigate the role of MCP-1 -2518 A/G polymorphism in the susceptibility to esophageal cancer in patients from Punjab, North-West India.
Methods: In this case-control study, 159 sporadic esophageal cancer patients and 159 age and gender matched controls were included. MCP-1 -2518 A/G promoter polymorphism was analyzed using PCR-RFLP method.
Results: The frequencies of GG, GA, and AA genotypes were 43.40%, 47.80% and 8.80% in patients, and 47.17%, 44.65%, 8.18% among the controls respectively. There were no significant differences in genotype and allele frequencies between the patients and controls.
Conclusion: In this study, we found no association between MCP-1 -2518 A/G polymorphism and the esophageal cancer risk in North-West Indians.
Keywords: Esophageal cancer, chemokines, MCP-1, polymorphism