A Better Perspective of Nuclear Atypia in Nottingham Prognostic Index: Study on Breast Carcinoma Patient Cohort from Eastern India
Dipti Rani Samanta *
Department of Medical Oncology, Acharya Harihar Regional Cancer Centre, Mangalabag, Cuttack, Odisha, India
Surendra Nath Senapati
Department of Radiation Oncology, Acharya Harihar Regional Cancer Centre, Cuttack, Odisha, 753007, India
Tapan Kumar Sahoo
Department of Radiation Oncology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, 751019, India
Puspanjali Khuntia
Department of Obstetrics and Gynaecology, S.C.B. Medical College, Cuttack, India
Saumyaranjan Mishra
Department of Radiation Oncology, Acharya Harihar Regional Cancer Centre, Cuttack, Odisha, 753007, India
Sandeep Satapathy
Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, 462066, India
Rabi Narayan Mallick
Patholab, Cuttack, Odisha, 753007, India
*Author to whom correspondence should be addressed.
Abstract
Aims: This paper uses the parameter-based correlation to Nottingham prognostic indexwith specific attempt for histologic grade/ nuclear atypia.
Place and Duration of the Study: The retrospective analysis was conducted at Acharya Harihar Regional Cancer Research Centre and Hospital, Cuttack, Odisha within a period of 6 years starting from 2008 to 2013.
Methodology: In this paper we have done retrospective analysis of the histopathological data of 1372 breast carcinoma patients from eastern India and subjected to different regimens of therapy and patient health constitution driven treatment outcome. This paper uses the parameter-based correlation to NPI with specific attempt for histological grade/ nuclear atypia.
Statistical Methods: SPSS version 22.
Results: The results of the study gives a impression that the correlation of NPI and histologic grade bears statistical significance and especially nuclear atypia and mitotic activity are two of those parameters with higher significance of correlation with NPI.
Conclusion: Nuclear atypia as seen from multivariate analysis and correlation study can be a better prognostic marker for a range of values with most the confidence interval being up to 3.71.
Keywords: Nuclear atypia, histological grade, Nottingham prognostic index, breast cancer, tumor size, nodal involvement